THE SCIENCE OF THE BYPASS: TRANSDERMAL BIOAVAILABILITY
THE ARCHITECTURAL STANDARD IN NUTRIENT DELIVERY
The Patch Protocol was engineered to solve a fundamental physiological failure: the Gastric Barrier. Traditional oral supplements rely on a digestive system that is often compromised by slowed motility, high acidity, and first-pass hepatic metabolism.
Our medical-grade transdermal matrix bypasses the digestive tract entirely, delivering a steady-state stream of micronutrients directly into the bloodstream through the dermis.
THE MECHANISM: HOW THE BYPASS WORKS
1. Bypassing First-Pass Metabolism
When you ingest a pill, it must survive stomach acid and the liver's "first-pass" filtration. This process can degrade up to 90% of the active ingredients before they reach systemic circulation. The Patch Protocol utilizes a Polymer Matrix Delivery System that ensures nutrients enter the capillaries directly, maintaining a higher concentration of active compounds.
2. Solving for Gastric Delay
For individuals utilizing GLP-1 medications or those with metabolic sensitivities, the stomach’s emptying process is significantly slowed. This "Gastric Delay" makes oral vitamins unpredictable and often triggers nausea. By skipping the gut, our protocol provides reliable, nausea-free support regardless of digestive speed.
3. Controlled Kinetic Release
Oral supplements create a "Spike and Crash" in nutrient levels. Our patches are engineered for Sustained Kinetic Release, providing a consistent $C_{max}$ (maximum serum concentration) over a 12 to 24-hour period, avoiding the physiological stress of nutrient dumping.
COMPARATIVE BIOAVAILABILITY
| Delivery Method | Absorption Rate | Digestive Interference | Systemic Load |
| Oral Capsules | 10% - 20% | High (Stomach Acid/Bile) | High (Liver/Kidneys) |
| Liquid Tinctures | 25% - 35% | Moderate (Enzymatic) | Moderate |
| THE PATCH PROTOCOL | 65% - 85% | Zero (Digestive Bypass) | Minimal |
CLINICAL REFERENCES & RESEARCH
The efficacy of transdermal delivery is supported by decades of clinical research in pharmacology and systemic nutrient therapy.
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Bypassing the Gastrointestinal Tract: A study on the advantages of transdermal delivery over oral administration for nutrient absorption and avoiding "first-pass" metabolism.
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Transdermal Delivery Systems in Modern Medicine: An analysis of the kinetic release profiles of matrix-style patches.
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Bioavailability of Micronutrients via Dermal Absorption: Research regarding the systemic uptake of vitamins and minerals through the skin barrier.
THE PROTOCOL QUALITY STANDARD
Every patch is manufactured in an ISO-Certified Facility using medical-grade adhesives and hypoallergenic materials. We do not use fillers, synthetic binders, or artificial colors found in traditional oral supplements.
This is not a supplement. This is a Systemic Delivery Protocol..